A push currently exists to design materials capable of handling harsher environments, including radiation dose and temperatures, for current fission reactor applications such as long-term (>40+ years) operation and advanced fission reactors. Such harsh extremes, for any of these applications, could lead to significant changes in known radiation-induced processes such as radiation hardening and embrittlement, radiation induced/enhanced precipitation, radiation-induced segregation (RIS), irradiation creep, volumetric swelling, and helium embrittlement. To overcome and perform in these environments novel processing routes or new materials must be explored that can increase the radiation tolerance of the selected material system and significantly reduce one or all of these radiation-based effects.